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Entecavir and tenofovir work well for people with drug-resistant hepatitis B virus
Liz Highleyman, 2014-12-22 09:10:00
A combination of entecavir plus tenofovir effectively suppressed hepatitis B virus (HBV) in people with resistance to other antivirals, according to results from the European ENTEBE study presented at the American Association for the Study of Liver Diseases (AASLD) Liver Meeting last month in Boston. Another study, however, showed that for some resistant patients, tenofovir works equally well on its own.
Antiviral therapy using nucleoside/nucleotide analogues such as entecavir (Baraclude), tenofovir (Viread), adefovir (Hepsera) or lamivudine (Epivir) is the mainstay of chronic hepatitis B treatment. Although they effectively suppress HBV replication during therapy, they typically do not eradicate the virus and may be used long-term. But HBV often develops resistance to antivirals -- especially the oldest drug, lamivudine -- which can lead to treatment failure.
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