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US CDC recommends HPV vaccine for young men
Keith Alcorn, 2012-02-06 08:50:00
Young men and adolescent boys between the ages of 11 and 21 should be vaccinated against human papillomavirus, the cause of genital warts, anal and cervical cancer, the Advisory Committee on Immunization Practices has recommended, in a new Adult Immunization Schedule published in Annals of Internal Medicine.
The committee also recommends that all gay and bisexual men and HIV-positive men aged 26 and under should be vaccinated.
US guidelines already recommend that young women and girls aged 11 to 26 should receive the vaccination.
In the United Kingdom HPV vaccination is offered to girls aged 12 to 13 through a National Health Service vaccination programme, although girls in the 14-17 age group can also be vaccinated.
At present the only HPV vaccine licensed for use in males is Gardasil, manufactured by Merck, which protects against four cancer-causing types of HPV (types 6, 11, 16 and 18). Gardasil is licensed for use in boys aged 9 – 15 years in the United Kingdom.
Vaccination has been shown to reduce the subsequent risk of genital warts, precancerous cervical changes and cervical cancer in women. In young men the vaccine has been shown to reduce the risk of HPV infection.
In an accompanying editorial Dr Sandra Fryhofer of Emory University, Atlanta, notes that although clinical data are not available, the rationale that vaccination also protects against oropharyngeal cancers caused by HPV is “certainly plausible”.
A recent review of the impact of HPV vaccination in Melbourne, Australia, found that the risk of young men and women under 21 being diagnosed with genital warts fell by approximately 60% between 2007/8 and 2010/11 among patients attending the Melbourne Sexual Health Centre. This followed the implementation of a vaccination programme in girls and women aged 26 and under from 2007 onwards.
The number of sexual partners did not affect the reduction in risk.
In contrast new diagnoses of genital warts did not fall significantly in heterosexual women and men aged 30 and over, nor in men who have sex with men, indicating that these groups are not benefiting from the effect of the current vaccination policy.
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