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Women in PrEP trial feared they would have to leave study if they reported low adherence
Gus Cairns, 2015-04-10 07:20:00
Post-study interviews and computer questionnaires conducted with former participants in a trial of pre-exposure prophylaxis (PrEP) that reported zero effectiveness show that participants concealed their low adherence to the study pills because, despite reassurances from researchers, they feared they would be asked to leave the study.
The interviews reveal that some participants went to elaborate lengths to disguise their low adherence – underlining that, while they had doubts about the value of the intervention on offer, they greatly valued the medical care that the study offered.
The researchers comment that “The appropriate level of ancillary care to be provided in biomedical HIV prevention clinical trials has been a longstanding ethical discussion in the field. Individuals may continue to enrol in clinical trials as a means to obtain ancillary healthcare until these needs can be otherwise sufficiently met.”
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