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Tenofovir impairs enzyme that stops cells ageing
Gus Cairns, 2013-01-31 10:00:00
A team of Australian researchers has found that tenofovir and, to a lesser extent, other drugs from the nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) class, impairs an enzyme that slows down or stops ageing processes in immune cells in the test tube.
They also found that, in people living with HIV, a marker of cell age called telomere length showed that both older age and duration of treatment with NRTI drugs were significantly associated with signs of the senescence (biological ageing) and approaching death of immune system cells, and that the enzyme that protected cells against this process was less active.
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