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Two interferon-free regimens show high HCV cure rates for people with HIV and HCV co-infection
Liz Highleyman, 2015-02-27 12:20:00
A pair of two-drug, 12-week regimens containing neither interferon nor ribavirin – sofosbuvir (Sovaldi) plus either ledipasvir (the Harvoni coformulation) or daclatasvir (Daklinza) – cured hepatitis C for more than 95% of people with HIV and hepatitis C co-infection, according to two presentations at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) this week in Seattle, USA. These findings confirm that people living with HIV who have hepatitis C can be treated the same as those with hepatitis C alone.
The advent of oral direct-acting antiviral agents (DAAs) that target different steps of the hepatitis C virus (HCV) lifecycle have revolutionised treatment, offering therapy that is shorter, better tolerated, and more effective than interferon-based therapy. This is particularly beneficial for people with HIV and HCV co-infection who tend to have more rapid liver disease progression and do not respond as well to interferon.
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