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How a London clinic reduced new HIV infections by 90% and why more European cities can do the same
Keith Alcorn, 2017-10-26 14:00:00
Scaling up HIV testing to reduce undiagnosed HIV infection
requires a fundamental re-ordering of HIV testing services to make them more
attractive to people at risk, and doing so can bring about enormous changes in
HIV incidence and treatment uptake, delegates heard on the opening day of the
16th European AIDS Conference (EACS 2017) in Milan.
Over the past three years, one clinic in London has seen
recent HIV infections among gay and bisexual men using its services fall by
around 90%. The experience of the 56 Dean Street clinic, in the heart of
London’s West End, illustrates how services may need to change to improve rates
of HIV diagnosis, increase the numbers of people on treatment and reduce new
HIV infections among key populations, especially men who have sex with men.
Similar services are also emerging in other European cities,
notably the Checkpoint clinic in Barcelona that is now being replicated in
Portugal and Italy, but the London data are the first evidence that services
offering new models of high throughput, community-based care that incorporate
HIV treatment and pre-exposure prophylaxis (PrEP) can have a transformational effect on a city’s epidemic.
Dr Emma Devitt of Chelsea and Westminster Hospital, London, explained
how the service developed, and its impact, in a special round table session on
HIV testing and PrEP. Her presentation showed that although the 56 Dean Street
clinic was first, everything done at the clinic could be put into practice in
other cities – provided that PrEP can be offered and clinicians can build
partnerships and trust with key populations such as men who have sex with men.
The clinic opened in 2009 with a focus on reducing
undiagnosed HIV infection. The clinic offers sexual health, HIV and hepatitis
diagnosis and treatment services, as well as specialist services for at-risk
populations including sex workers and the trans community, and has developed a
PrEP monitoring service and a chemsex clinic as the needs have emerged among men who have sex with men.
Use of the service expanded rapidly, from 39,042 users in
2009-10 to 64,068 users in 2012-13. The huge increase in demand convinced
clinic managers that further expansion was needed, so in 2014 a second service,
Dean Street Express, opened on the same street.
Dean Street Express is a largely automated clinic designed
to improve screening for asymptomatic sexually transmitted infections (STIs). Touch-screen questionnaires
determine what tests are needed. Service users then go into a booth to carry
out self-sampling tests for HIV and STIs (a video in
the booth explains how to do the self-sampling).
Samples are processed using the Cepheid Gene Xpert platform
which can handle 900 samples per day. Results are sent to the service user
within hours by text message; if treatment is needed the text includes a link
to make an immediate appointment. On average, results are delivered within four
hours and the time from testing to treatment has fallen from just under ten
days to two days.
Dean Street Express has been phenomenally successful. In its
first month of operation 2968 people attended the clinic. In July 2015, 8454
people attended the clinic. By 2016, the Dean Street clinics carried out 25% of
all STI tests in men who have sex with men in England and diagnosed 30% of all gonorrhoea cases in men who have sex with men in England.
The success of this service has given Dean Street a unique
opportunity to intervene to halt HIV transmission among men who have sex with
men in London. A total of 12,500 people attend the clinics each month, 60% of them men who have sex with men. The
clinics diagnose half of all HIV infections in men who have sex with men in
London, and of these, half are recent infections.
But the number of new HIV diagnoses has
fallen from 60-70 a month at the end of 2015 to ten in September – and so far,
in October, just three people have been diagnosed with HIV.
What is the reason for this dramatic fall, which is also
being seen at other large clinics in London that have adopted elements of the
Dean Street model? Considering the change in diagnoses on a quarterly basis,
the decline first became evident within months of introducing rapid treatment
initiation for seroconverters, accelerated after the results of the PROUD study
promoted community activism to obtain generic drugs for PrEP and fell even more
sharply after the clinic introduced a standard offer of antiretroviral
treatment within 48 hours of HIV diagnosis.
Dean Street clinicians say that the decline in new diagnoses
is most likely due to the range of things that the clinic does. For example,
the high rate of STI diagnosis means that for every two bacterial STIs
diagnosed, a further person is spared exposure. STIs are treated eight days
faster, reducing potential onward transmission and reducing the likelihood that
STIs can contribute to HIV transmission.
Frequent HIV testing, early diagnosis and rapid treatment
initiation are enormously important. So too is the clinic’s central role in
pioneering support for PrEP use in men who have sex with men, by offering
monitoring to people who are using generic PrEP. As well as ensuring that PrEP
is used safely, the service also encourages more frequent testing for HIV and
A letter published this week in Sexually Transmitted Infections by clinicians from 56 Dean Street
shows that a spot sample of HIV-negative men who have sex with men attending 56 Dean Street for
asymptomatic STI screening in April 2017 found that 15% of those potentially
eligible for PrEP were already using it. So, generic PrEP use has been a
contributory factor, but certainly it is not sufficient on its own to account
for the large reduction in HIV diagnoses.
Recent research by Public Health England (presented
earlier this year at the British HIV Association conference) shows that at
the London clinics which have seen sharp falls in HIV diagnoses in 2016 the
number of men with HIV with detectable viral load as a proportion of the
population of men at high risk (those diagnosed with an STI in the previous
year) is markedly lower than at other clinics in England. In other words, fewer
men have the potential to pass on HIV in these clinic populations.
Other intangible factors are also important to the clinic’s
success. As well as becoming well known as a gay-friendly clinic that is very
responsive to user needs – for example, by providing non-judgemental services to
support chemsex use – 56 Dean Street has not been afraid to talk clearly about
PrEP use, the importance of sexual pleasure and intimacy.
“Viral undetectability is an urgently desired status and
doctors should use that as a motivation for treatment,” said Gus Cairns of
NAM aidsmap in a panel discussion following the presentation.
Other models of community-based clinics will be needed to
expand access to treatment and PrEP in Eastern Europe, panellists agreed.
Integrated treatment and PrEP services also need to alter their models to
attract more young people and other key populations by thinking about how they
want clinical services to work.
Jean-Michel Molina, who received the EACS award for
Excellence in HIV Medicine for his work on the Ipergay trial of on-demand PrEP,
said “We are not doing enough to enrol young MSM [men who have sex with men], migrants from high-burden
countries and trans [on PrEP].”
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