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Experimental STI prophylaxis in PrEP users produces big drops in syphilis and chlamydia infections but not in gonorrhoea
Gus Cairns, 2017-02-15 20:10:00

Use of the antibiotic doxycycline as on-demand post-exposure prophylaxis by men who have sex with men (MSM) taking part in the Ipergay HIV PrEP trial produced a 70% drop in chlamydia infections and a 73% drop in syphilis, but no reduction in gonorrhoea. The results were presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2017).

The antibiotic prophylaxis is described as post-exposure because trial subjects were told to take it after episodes of risky sex. But they were provided with two months’ supply of the drug per visit and could take up to a maximum of six pills per week.

This is the second test of this concept, though the first study, in 2015, only recruited 30 men – see this report.