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Maviret cures most people with HCV genotype 3 and those with cirrhosis
Liz Highleyman, 2017-10-24 12:00:00

Glecaprevir and pibrentasvir, the two drugs in the recently approved Maviret co-formulation, demonstrated high sustained response rates for people with chronic hepatitis C virus (HCV) genotype 3 and for people with liver cirrhosis, according to a pair of reports presented at the 2017 AASLD Liver Meeting this week in Washington, DC.

An integrated analysis of clinical trial data showed that glecaprevir/pibrentasvir taken for 8 weeks cured 98% of people without cirrhosis with hard-to-treat genotype 3, while a 12-week course cured 100% of people with genotype 3 with cirrhosis. A related analysis showed that the combination taken for 12 or 16 weeks cured 96% of people with compensated cirrhosis across all genotypes.

Direct-acting antivirals used in interferon-free regimens can now cure most people with chronic hepatitis C virus, including people who were previously considered difficult to treat, such as those with genotype 3, advanced liver or kidney disease, or HIV/HCV co-infection.

AbbVie's Maviret (marketed as Mavyret in the US), which was approved in August, contains the HCV NS3/4A protease inhibitor glecaprevir and the NS5A inhibitor pibrentasvir. Both drugs are pangenotypic, meaning they are active against all HCV genotypes.