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Gene therapy snips HIV out of infected cells and makes uninfected cells resistant
Gus Cairns, 2016-03-30 10:50:00
For the first time, researchers have used a gene-editing
technique already used to produce cells resistant to HIV infection to target HIV-infected cells, remove
HIV genes completely from infected cells and inhibit viral production, and to produce cells that could be rendered resistant to infection by means of an injection.
The therapy produced significant reductions in the ability of
CD4 cells to be infected with HIV and to produce it, in both a
laboratory-generated CD4-cell analogue and in actual CD4 cells, both HIV-uninfected ones grown in the laboratory, and HIV-infected ones taken from four
patients with HIV.