Women with HIV on effective antiretroviral treatment in higher-income settings who have undetectable viral load should be supported to make their own decisions about breastfeeding based on a full discussion of the risks and benefits, rather than being discouraged from breastfeeding, a group of Swiss doctors has concluded after reviewing the available evidence.
Their opinion – and discussion of the evidence – is published in the open-access journal Swiss Medical Weekly.
They argue that in the absence of evidence that transmission does occur through breastfeeding when a woman has an undetectable viral load, the onus is on healthcare workers to provide unbiased information about the potential risks and benefits of breastfeeding to women living with HIV, and to support women in whatever choice they make.
In resource-limited settings the World Health Organization recommends that women living with HIV should take antiretroviral therapy and breastfeed for 12-24 months. This guidance reflects the protective effect of breastfeeding against infant mortality in resource-limited settings.
In higher-income settings national guidelines continue to discourage breastfeeding by mothers with HIV who are taking antiretroviral therapy, with few exceptions. A recent review of the scientific literature highlighted unanswered scientific questions.
But a group of Swiss doctors has now joined their British counterparts in questioning whether breastfeeding should be discouraged entirely.
The group, which includes paediatricians and specialists in obstetrics and gynaecology from some of the main hospitals providing care to people living with HIV in Switzerland, carried out a review of the scientific literature published since 2009 to identify any reported cases of HIV transmission through breastfeeding when the mother had a viral load below 50 copies/ml, was in continuous care and was fully adherent to antiretroviral treatment. They describe this as the 'optimal scenario', and point out that in an analysis of pregnant women who gave birth between 2012 and 2016 in the Swiss HIV Cohort, 95.9% of mothers already had a fully suppressed viral load at the time of delivery, indicating that this scenario is likely to be widely applicable.
Previous reviews of the scientific literature have been less strict regarding evidence of full viral suppression and have drawn attention to cases of transmission where it is difficult to be certain if the mother had a fully suppressed viral load. A randomised study of antiretroviral therapy or infant prophylaxis during breastfeeding (the PROMISE study) found that the risk of transmission was approximately 0.3% six months after delivery and 0.7% 12 months after delivery.
But the authors of the Swiss review point out that there is no evidence available on viral load suppression throughout the follow-up period in the PROMISE study, meaning that it is not possible to determine whether any transmission that took place during this study occurred in the conditions of the 'optimal scenario'. They did not identify any other documented cases of HIV transmission through breastfeeding in this scenario.
The review authors say that this leaves a situation of clinical equipoise – genuine scientific uncertainty – and that doctors should engage in shared decision-making with women living with HIV about infant feeding decisions.
The review authors suggest that the following points should be communicated to women when infant feeding is discussed, after discussing the woman’s preferences regarding feeding. Women should be informed that whatever decision they make, they will be supported by their healthcare team.
