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Treatment-as-prevention study sees substantial levels of transmitted drug resistance in participants, but no impact on treatment
Gus Cairns, 2017-02-15 01:30:00
A study of
the prevalence of transmitted drug resistance in participants in the ANRS 12249 trial of treatment as
reported its main results at the International AIDS Conference in Durban last
year, has found that a substantial minority of participants in the trial had
HIV with resistance mutations against the virus.
was no evidence that pre-existing drug resistance had any impact on the success
of treatment. This is surprising, and contrary to previous findings; trial investigator
Anne Derache told the Conference on Retroviruses and Opportunistic Infections (CROI 2017) that longer follow-up was needed to find whether
people with drug resistance would maintain undetectable viral loads.