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Treatment-as-prevention study sees substantial levels of transmitted drug resistance in participants, but no impact on treatment
Gus Cairns, 2017-02-15 01:30:00

A study of the prevalence of transmitted drug resistance in participants in the ANRS 12249 trial of treatment as prevention, which reported its main results at the International AIDS Conference in Durban last year, has found that a substantial minority of participants in the trial had HIV with resistance mutations against the virus.

However, there was no evidence that pre-existing drug resistance had any impact on the success of treatment. This is surprising, and contrary to previous findings; trial investigator Anne Derache told the Conference on Retroviruses and Opportunistic Infections (CROI 2017) that longer follow-up was needed to find whether people with drug resistance would maintain undetectable viral loads.