Featured news from NHIVNA
HIV-related news from NAM
Restoring and maintaining a high CD4 count possible for vast majority of people living with HIV in France
Alain Volny-Anne, 2014-11-12 12:50:00
A large French study has shown that the vast majority of people living with HIV who started treatment since 2000 in a national cohort achieved a CD4 cell count in the normal range within three to four years of starting treatment, while a large Italian study showed that achieving a normal CD4 count on treatment greatly reduced the risk of cancer and other serious non-AIDS illnesses.
The findings were presented last week at the HIV Drug Therapy Glasgow conference.
Reaching and maintaining a high CD4 cell count is one of the main objectives of antiretroviral therapy (ART), in order to provide patients with long-term protection against both AIDS-defining and non-HIV related diseases, commonly called co-morbidities. The CD4 recovery, expected from treatment, usually follows the suppression of viral load.
A team of French researchers assessed CD4 cell recovery in treatment-naive patients (people who had not previously taken treatment) who had initiated ART with at least three drugs after 2000. Participants in the study were followed for between two and seven years (median 65 months). Patients also had to have a suppressed viral load nine months after the initiation of their therapy to be eligible for inclusion in this analysis. This research was based on data from the French Hospital Database on HIV.
The second objective of the research was to look at patients’ baseline characteristics that were associated with achieving a CD4 cell count over 500.
Data from 13,912 people were analysed. Their median age was 39, and two-thirds were men. When beginning ART, their median CD4 cell count was 226 and 18.5% had experienced a prior AIDS event. One-in-ten participants had hepatitis C co-infection, and one-in-ten had been diagnosed during primary HIV infection.
In the analysis, patients were stratified by CD4 cell counts at ART initiation:
- Less than 200 – 5909 patients
- 200-350 – 5751 patients
- 350-500 – 2252 patients.
The proportion of patients who had a CD4 cell count above 500 cells/mm3 is shown in the table.
|
Baseline CD4 cell count |
Year 1 |
Year 2 |
Year 3 |
Year 4 |
Year 5 |
Year 6 |
Year 7 |
|
Less than 200 |
8% |
21% |
33% |
43% |
52% |
60% |
61% |
|
200 - 350 |
40% |
61% |
73% |
81% |
85% |
88% |
90% |
|
350 - 500 |
74% |
87% |
91% |
94% |
95% |
96% |
97% |
After five years of ART, a high CD4 cell count had been achieved by 85% of those with a baseline CD4 between 200 and 350 cells/mm3, and 95% of those with a baseline CD4 above 350 cells/mm3. Moreover, the results show that CD4 cell counts continued to increase seven years after starting antiretroviral therapy, independently of baseline levels.
Although failing to achieve a CD4 recovery was a rare outcome for patients new to treatment in this cohort, recovery took substantially longer in patients who initiated ART with low CD4 counts. After five years on treatment, only half of patients with a baseline CD4 cell count below 200 had achieved a CD4 cell count above 500 and even after seven years, almost 40% of people who started treatment late still had a CD4 cell count below 500 cells/mm3.
People with a higher CD4 count before initiating ART, as well as those who began treatment during primary infection, were more likely to have a full CD4 recovery within seven years. Moreover, individuals whose first ART regimen was an integrase inhibitor and two nucleoside reverse transcriptase inhibitors were more likely to achieve a high CD4 cell count.
Source:1
