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Care programme improves clinic attendance and rates of virologic suppression among vulnerable HIV-positive patients in New York
Michael Carter, 2014-10-14 08:40:00
Enrollment in a comprehensive care coordination programme significantly improves levels of engagement with HIV care and virologic suppression in vulnerable HIV-positive adults, according to research published in the online edition of Clinical Infectious Diseases. The research was conducted in New York City and involved over 3600 patients who either had previous poor engagement with care or were newly diagnosed. Their package of support included case-finding after missed appointments; individual case management; a multi-disciplinary care team; accompanied clinic visits; adherence support and structured health promotion information.
Patients were followed for one year and the intervention was shown to have a “substantial and robust impact.”
Improvements in antiretroviral therapy mean that many HIV-positive patients now have an excellent life expectancy. HIV treatment also has public health benefits as an undetectable viral load is associated with a zero or extremely low risk of passing on the infection to sexual partners.
However, patients can only benefit from HIV therapy if they engage with the care continuum or treatment cascade. This involves diagnosis; linkage to care; ongoing engagement with care; appropriate use of HIV therapy; adherence to therapy; and achievement of an undetectable viral load.
In the US, between 72%-80% of those diagnosed with HIV are linked to care and further attrition occurs at each stage of the treatment cascade with only 24%-42% of patients achieving virologic suppression.
Strategies and interventions are therefore urgently needed to improve outcomes.
In 2009, New York City’s Ryan White part A HIV Care Coordination Program was launched at 29 agencies. Investigators wanted to determine the short-term impact of participation in this project, which provides support to patients at high risk of poor HIV-related outcomes.
The study outcomes were engagement in (at least two CD4 and/or viral load evaluations 90 days apart, with at least one assessment in each six-month period of the study) and virological suppression (a viral load below 200 copies/ml in the second six-month period).
Patients were categoried as newly diagnosed if they were diagnosed with HIV in the twelve months before enrollment in the study, and as previously diagnosed if they had been diagnosed for more than twelve months. Previously diagnosed patients were defined as out of care if they had not had a CD4/viral load evaluation in the six months prior to enrollment.
Most of the participants were black or Hispanic (92%), male (63%) and US born (66%). The median age at enrollment was 45 years, and 46% of patients had a CD4 count below 350 cells/mm3. At the start of the study, 74% were current to care, 14% were out of care and 13% were newly diagnosed.
Among the previously diagnosed patients, engagement with care increased from 74% to 91% and the proportion of patients with virological suppression increased from 32% to 51%. The best improvements were seen in patients who had previously been out of care for at least six months.
Analysis of the newly diagnosed patients showed that 91% were engaged with care and 66% achieved a viral load below 200 copies/ml.
The investigators were especially encouraged that the greatest relative improvements in engagement and/or suppression were seen in the most vulnerable patients, for instance those without an antiretroviral prescription at enrollment, individuals on a low income, patient with no health insurance and the homeless.
“Among vulnerable populations with HIV, comprehensive care coordination may substantially improve short-term outcomes for previously diagnosed clients, especially those returning to care after a >6 month gap. Newly diagnosed clients in this study also fared well,” conclude the authors. “Our initial analyses of short-term care coordination program client outcomes suggest the promise of this comprehensive combination intervention model for optimizing the individual and community impact of HIV care among persons at risk for suboptimal outcomes.”
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