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Dolutegravir shows good efficacy across broad range of patient groups
Liz Highleyman, 2013-09-17 10:00:00
The new integrase inhibitor dolutegravir worked better than boosted darunavir for people starting HIV treatment for the first time, researchers reported last Thursday at the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Denver. Another study found that dolutegravir worked well across sex, ethnicity and age groups.
ViiV Healthcare's dolutegravir, recently approved by the US Food and Drug Administration under the brand name Tivicay and currently awaiting European Medicines Agency approval, was the topic of several presentations at ICAAC.
Approval was based on favourable results from the phase 3 VIKING and SAILING trials in treatment-experienced patients and the SINGLE and SPRING studies in previously untreated people. SINGLE tested dolutegravir plus abacavir/lamivudine (the drugs in Kivexa) against Atripla (efavirenz/tenofovir/emtricitabine single tablet regimen), whilst SPRING-2 compared dolutegravir versus raltegravir (Isentress), the only other approved integrase inhibitor.
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