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Sofosbuvir + ribavirin is safe and effective for people with hepatitis C who have advanced liver disease
Liz Highleyman, 2014-04-16 17:00:00

Sofosbuvir plus ribavirin is a safe option that can lead to sustained response in people with advanced liver disease including those with decompensated cirrhosis and portal hypertension, and people who experience severe hepatitis recurrence after a liver transplant, researchers reported last week at the 49th Annual Meeting of the European Association for the Study of the Liver (EASL) in London.

Over years or decades, chronic hepatitis C virus (HCV) infection can lead to severe liver complications including cirrhosis, hepatocellular carcinoma, end-stage liver disease and the need for a liver transplant. People with advanced liver disease are in most dire need of treatment, but interferon can be difficult to tolerate and potentially dangerous, and is therefore contraindicated for these sickest patients.

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