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No transmission of integrase inhibitor-resistant HIV seen in California patients
Gus Cairns, 2015-10-09 08:00:00
Not one case of transmission of HIV that is resistant to any of the integrase inhibitor (INI) drugs has been seen in newly-diagnosed patients in a database of resistance tests in California, the ICAAC 2015 conference heard last month.
The reasons for this are unclear, given that integrase inhibitor resistance that arises on treatment is not that uncommon. Because of this it was anticipated that INI resistance would inevitably arise and start circulating in the pool of viruses being transmitted, especially as acquired INI resistance actually develops rather more frequently than resistance to protease inhibitors – which does get transmitted.
The researchers commented that more data from a larger patient group was needed to confirm these observations and to find the reason for the apparent rarity of transmitted INI resistance.
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